Hepatit C ve kafein..
Kahvenin karaciğeri koruyucu etkisi daha öncede bilinmekte idi. Bu çalışma saygın bir tıp dergisinde yayınlandı ve bu bilgiye yeni bir destek sağladı.
Günde 3 kap ya da daha fazla kahve içen Hepatit C olgularında karaciğer'de düzelme saptanıyor.
Journal of Hepatology
Volume 54, Issue 6, June 2011, Pages 1123-1129
Research Article
Association of caffeine intake and histological features of chronic hepatitis C
Charlotte E. Costentin1, Françoise Roudot-Thoraval2, 3, 4, Elie-Serge Zafrani2, 3, 5, Fatiha Medkour1, Jean-Michel Pawlotsky2, 3, 6, Ariane Mallat1, 2, 3 and Christophe Hézode1, 2, 3, ,
1 AP-HP, Service d’Hépatologie et de Gastroentérologie, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil 94000, France
2 INSERM, U955, Créteil 94000, France
3 Université Paris-Est, Faculté de Médecine, UMR-S955, Créteil 94000, France
4 AP-HP, Service de Santé publique, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil 94000, France
5 AP-HP, Service d’Anatomo-pathologie, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil 94000, France
6 AP-HP, Service de Virologie, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil 94000, France
Received 23 April 2010; revised 1 August 2010; accepted 20 August 2010. Available online 22 October 2010.
Background & Aims
The severity of chronic hepatitis C (CHC) is modulated by host and environmental factors. Several reports suggest that caffeine intake exerts hepatoprotective effects in patients with chronic liver disease. The aim of this study was to evaluate the impact of caffeine consumption on activity grade and fibrosis stage in patients with CHC.
Methods
A total of 238 treatment-naïve patients with histologically-proven CHC were included in the study. Demographic, epidemiological, environmental, virological, and metabolic data were collected, including daily consumption of alcohol, cannabis, tobacco, and caffeine during the six months preceding liver biopsy. Daily caffeine consumption was estimated as the sum of mean intakes of caffeinated coffee, tea, and caffeine-containing sodas. Histological activity grade and fibrosis stage were scored according to Metavir. Patients (154 men, 84 women, mean age: 45 ± 11 years) were categorized according to caffeine consumption quartiles: group 1 (<225 mg/day, n = 59), group 2 (225–407 mg/day, n = 57), group 3 (408–678 mg/day, n = 62), and group 4 (>678 mg/day, n = 60).
Results
There was a significant inverse relationship between activity grade and daily caffeine consumption: activity grade >A2 was present in 78%, 61%, 52%, and 48% of patients in group 1, 2, 3, and 4, respectively (p <0.001). By multivariate analysis, daily caffeine consumption greater than 408 mg/day was associated with a lesser risk of activity grade >A2 (OR = 0.32 (0.12–0.85). Caffeine intake showed no relation with fibrosis stage.
Conclusions
Caffeine consumption greater than 408 mg/day (3 cups or more) is associated with reduced histological activity in patients with CHC. These findings support potential hepatoprotective properties of caffeine in chronic liver diseases.
Keywords: Caffeine; Hepatitis C virus; Chronic hepatitis C
